abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) and lung cancer are the leading causes of morbidity and mortality worldwide. The current research is focused on identifying the common and disparate events involved in epigenetic modifications that concurrently occur during the pathogenesis of COPD and lung...

journal_title：Current opinion in pulmonary medicine

authors： Sundar IK,Mullapudi N,Yao H,Spivack SD,Rahman I

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Ventilator-associated pneumonia (VAP) remains a frequent and severe complication in endotracheally intubated patients. Strict adherence to preventive measures reduces the risk of VAP. The objective of this paper is to review what has come forward in recent years in the nonpharmacological prevention of...

journal_title：Current opinion in pulmonary medicine

authors： Blot S,Rello J,Vogelaers D

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) represent two of the most prevalent chronic respiratory disorders and cardiovascular diseases are major co-morbidities in both. Co-existence of both disorders (overlap syndrome) occurs in 1% of adults and overlap patients h...

journal_title：Current opinion in pulmonary medicine

authors： Lee R,McNicholas WT

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:although long-acting beta-agonists (LABAs) have been used for two decades, with many studies showing benefit versus increasing inhaled corticosteroid (ICS), controversy regarding safety has resulted in the United States Food and Drug Administration (FDA) recently mandating label changes restricting LA...

journal_title：Current opinion in pulmonary medicine

authors： Sears MR

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews current data on pathophysiologic mechanisms by which sleep-disordered breathing during pregnancy may cause harm, and explores biological pathways for associated adverse maternal and fetal outcomes, especially pregnancy-induced hypertension and gestational diabetes. RECENT FINDING...

journal_title：Current opinion in pulmonary medicine

authors： Izci-Balserak B,Pien GW

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Regions of the neocortex most strongly activated during waking exhibit increased sleep intensity during subsequent sleep. The novel concept that aspects of sleep homeostasis are determined locally in the cortex contrasts with the established views that global changes in neocortical activity during sle...

journal_title：Current opinion in pulmonary medicine

authors： Szymusiak R

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Nuclear medicine techniques have the capacity to investigate neuronal dysfunction at the synapse level. For instance, metaiodobenzylguanidine (MIBG) shows a similar uptake, storage and release as norepinephrine. Intravenously injected radiolabeled MIBG is able to reflect neuronal damage induced by inf...

journal_title：Current opinion in pulmonary medicine

authors： van Kroonenburgh M,Mostard R,Vöö S

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Secondary spontaneous pneumothorax (SSP) can occur in patients who are suffering from diffuse lung disease. The main cause of SSP is chronic obstructive pulmonary disease (COPD). In contrast to primary spontaneous pneumothorax, SSP is a potentially life-threatening condition because patients with SSP ...

journal_title：Current opinion in pulmonary medicine

authors： Nakajima J

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although known for several decades, catamenial pneumothorax has been considered until recently as an extremely rare entity. The condition is now more easily recognized and several studies have been published, with somewhat relevant discrepancies with respect to etiologic, epidemiologic, and management...

journal_title：Current opinion in pulmonary medicine

authors： Alifano M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant central airway obstruction heavily impacts patients' quality of life and its management continues to be a challenge. The current article will review the use of airway stents in this population. RECENT FINDINGS:Airway stenting is highly effective in palliating symptoms of airway obstruction....

journal_title：Current opinion in pulmonary medicine

authors： Casal RF

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary cystic echinococcosis, a zoonosis caused by the larvae of the dog tapeworm Echinococcus granulosus, is considered as a major public health problem in countries where dogs are used to care for large herds. Despite its frequency and widespread endemicity, the literature on pulmonary cystic ech...

journal_title：Current opinion in pulmonary medicine

authors： Santivanez S,Garcia HH

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to summarize the evidence base for tuberculosis (TB) diagnostics, review recent policies on TB diagnostics, and discuss issues such as how evidence is translated into policy, limitations of the existing evidence base, and challenges involved in translating policies into impact. RECENT FIND...

journal_title：Current opinion in pulmonary medicine

authors： Pai M,Minion J,Steingart K,Ramsay A

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Time to clinical worsening (TTCW) can be used to assess disease progression associated with pulmonary arterial hypertension (PAH). As a consequence, it is highly relevant to patients, clinicians, and regulatory agencies. The majority of clinical trials of PAH-specific drug therapies have included TTCW...

journal_title：Current opinion in pulmonary medicine

authors： Galiè N,Simonneau G,Barst RJ,Badesch D,Rubin L

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work demonstrates that patients with refractory asthma are likely to be sensitized to environmental fungi and that specific antifungal treatments may be of benefit to this group. RECENT FINDINGS:The relationships among fungal sensitization, exposure and asthma severity are imperfectly understo...

journal_title：Current opinion in pulmonary medicine

authors： Gore RB

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Summarize recently published studies and critiques evaluating the effects of the American Academy of Sleep Medicine (AASM) Sleep Scoring Manual. RECENT FINDINGS:Only a few retrospective studies have been published evaluating the new AASM Scoring Manual. These have shown that when scoring polysomnogra...

journal_title：Current opinion in pulmonary medicine

authors： Grigg-Damberger MM

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent studies that have quantified the incidence of death due to late thromboembolic disease among patients initially diagnosed with acute unprovoked pulmonary embolism. These findings will aid clinicians who must weigh the risk versus the benefits of long-term anticoagulant therapy. RE...

journal_title：Current opinion in pulmonary medicine

authors： White RH,Murin S

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article aims to review the most recent proteomic findings in tissue and biological fluids and application of new technologies for the study of interstitial lung diseases. RECENT FINDINGS:New insights into lung cell biology as well as novel pathogenetic pathways of different interstitial lung dis...

journal_title：Current opinion in pulmonary medicine

authors： Rottoli P,Bargagli E,Landi C,Magi B

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Smoking is a major risk factor for lung cancer, which is the leading cause of cancer-related deaths both in the USA and worldwide. Chronic obstructive pulmonary disease and emphysema are comorbid conditions often found in lung cancer patients. The inflammatory pathways that link chronic obstructive pu...

journal_title：Current opinion in pulmonary medicine

authors： Lee G,Walser TC,Dubinett SM

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant pleural effusion (MPE) poses a common and significant clinical problem. Its pathogenesis is poorly understood and therapeutic options are limited. Herein are summarized animal models of MPE and their contributions in unveiling new aspects of the pathobiology of the condition. RECENT FINDING...

journal_title：Current opinion in pulmonary medicine

authors： Stathopoulos GT,Kalomenidis I

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Global climate change and population explosion leading to changes in natural ecosystem and travel across the continents have resulted in an increase in the transmission of parasites to human beings. This review focuses on recent advancements in parasitic lung infections. RECENT FINDINGS:Invasive para...

journal_title：Current opinion in pulmonary medicine

authors： Vijayan VK

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review highlights the clinical findings and the management of community-acquired, health-care associated and nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:Although previously considered as a purely nosocomial event, community-acquired MRSA pneumon...

journal_title：Current opinion in pulmonary medicine

authors： Tacconelli E,De Angelis G

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Symptoms of anxiety and depression are prevalent in at least 20-40% of patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) and are known to affect prognosis and worsen quality of life. This review examines whether pulmonary rehabilitation can effectively improve psychological...

journal_title：Current opinion in pulmonary medicine

authors： Coventry PA

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight seminal and current literature that informs our understanding of the clinical and investigative utility of biomarkers in asthma. Biomarkers derive from a variety of sources [bronchiolar lavage (BAL), sputum, exhaled breath, and blood], and have widely variant...

journal_title：Current opinion in pulmonary medicine

authors： Murugan A,Prys-Picard C,Calhoun WJ

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The Sleep Heart Health Study began in 1994 as a prospective cohort study of cardiovascular disease. The results of longitudinal analysis are not yet available, but numerous analyses of cross-sectional data have been published. This review provides an overview of study results so far. RECENT FINDINGS:...

journal_title：Current opinion in pulmonary medicine

authors： Gottlieb DJ

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis. RECENT FINDINGS:Available data are responsible for a lack of consensus regarding treatment of distal deep vein thrombosis. SUMMARY:One standard diagnostic approach of suspected deep vein t...

journal_title：Current opinion in pulmonary medicine

authors： Righini M,Bounameaux H

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine recent reports of serosal involvement in sarcoidosis. RECENT FINDINGS:Peritoneal sarcoidosis continues to be a rare manifestation of the disease. Patients with peritoneal disease tend to be women between the ages of 20 and 40 years, and most commonly present with ascites and abdominal pain...

journal_title：Current opinion in pulmonary medicine

authors： Iyer S,Afshar K,Sharma OP

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the principles of staging cancer as applied to nonsmall cell lung cancer. RECENT FINDINGS:The current staging system is under review for update. It is timely to review the principles of staging cancer to see how the nonsmall cell lung cancer staging system can be improved. Staging systems s...

journal_title：Current opinion in pulmonary medicine

authors： Filner JJ,Ost D

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Air leak after pulmonary lobectomy is a relatively common problem, which when persistent can be a cause of other postoperative morbidity as well as contributing to extended hospitalization. A number of methods have been proposed to prevent and treat air leakage, but none have proved incontrovertibly e...

journal_title：Current opinion in pulmonary medicine

authors： Ahmed A,Page RD

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Respiratory tract infections are a common reason for prescribing antibiotics, although not all of these infections require such therapy. Rapid diagnosis of etiology using point-of-care tests is a potentially useful way of reducing prescriptions of both unnecessary and unnecessarily broad-spectrum anti...

journal_title：Current opinion in pulmonary medicine

authors： Charles PG

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of thoracic surgery in pulmonary tuberculosis, in either a diagnostic or a therapeutic role, is well established. This review aims to underline the current indications for lung resection, surgical strategy and outcomes associated with surgery. RECENT FINDINGS:There has been a renewed interes...

journal_title：Current opinion in pulmonary medicine

authors： Naidoo R

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in patients with chronic obstructive pulmonary disease. The epidemiological and mechanistic evidence linking these disorders, however, is uncertain. RECENT FINDINGS:In patients with mild chronic obstructive pulmon...

journal_title：Current opinion in pulmonary medicine

authors： Sin DD,Man SF

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy associated clinical and social burdens have increased substantially in prevalence in the past decade. Coexisting asthma is a significant problem as food reactions tend to be more severe when they involve the lung. Food allergy also increases asthma morbidity in adults and children. RECEN...

journal_title：Current opinion in pulmonary medicine

authors： Ozol D,Mete E

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent developments in liver disease associated with cystic fibrosis. RECENT FINDINGS:The broad spectrum of hepatobiliary problems in cystic fibrosis includes specific alterations ascribable to the underlying defect as well as lesions of iatrogenic origin or that reflect the ef...

journal_title：Current opinion in pulmonary medicine

authors： Colombo C

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Recently, studies on large diverse populations have described important ethnic/racial differences in venous thromboembolism incidence, and sex has been reported as an important predictor of recurrence. We review the influence of race/ethnicity and sex on venous thromboembolism, concentrating on ar...

journal_title：Current opinion in pulmonary medicine

authors： Keenan CR,White RH

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the recent advancements of the epidemiology, pathophysiology, clinical characteristics, radiographic studies, diagnostic modalities, treatment, and prognosis of pulmonary hypertension in sarcoidosis. RECENT FINDINGS:A large retrospective study found 73.8% of patients with sarcoidosis liste...

journal_title：Current opinion in pulmonary medicine

authors： Shigemitsu H,Nagai S,Sharma OP

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Since the introduction especially of multidetector computed tomography scanners, detection of peripheral pulmonary nodules as small as 2-3 mm is now a frequent event even in individuals without a significant smoking history. This preponderance of small indeterminate nodules has necessitated reconsider...

journal_title：Current opinion in pulmonary medicine

authors： Shiau MC,Bonavita J,Naidich DP

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent data detailing the prevalence and characteristics of pleural effusions occurring in patients with superior vena cava syndrome. RECENT FINDINGS:Numerous case reports have described pleural effusions in conjunction with the superior vena cava syndrome. Recent data suggest ...

journal_title：Current opinion in pulmonary medicine

authors： Rice TW

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Parasitic pneumonia is being increasingly reported from many parts of the world due to globalization and travel across the continents. This review outlines the recent developments in the diagnosis and management of parasitic pneumonias. RECENT FINDINGS:A polymerase chain reaction that can differentia...

journal_title：Current opinion in pulmonary medicine

authors： Vijayan VK

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There is growing evidence that genetics plays a role in the development of chronic obstructive pulmonary disease. This review deals with the most recent findings, new methods to detect genetic susceptibility that may be helpful in this field, and how the environment may act on the genetic code of susc...

journal_title：Current opinion in pulmonary medicine

authors： Molfino NA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Asthma is a heterogeneous disorder presenting with many phenotypes. Precise phenotypic definition has eluded the medical research community for years, despite recognition of different disease subtypes. Improved phenotypic characterization and knowledge of underlying pathobiology is necessary for linka...

journal_title：Current opinion in pulmonary medicine

authors： Kiley J,Smith R,Noel P

更新日期：2007-01-01 00:00:00